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Differin® Gel contains adapalene, a type of retinoid. Topical retinoids, like Differin® Gel, play a crucial role in the treatment of acne. Retinoids have vitamin A activity which helps regulate cell turnover to make sure your skin goes through the right process, creating a healthier environment for skin. Regulating cell turnover helps to keep the pores from clogging and target acne before it even starts. Don’t think of Differin® Gel as a spot treatment only to be used when acne rears its ugly head. In fact, if used daily, Differin® Gel stops new acne from forming, resulting in improved skin tone and texture.

Differin contains the only full prescription fighting retinoid available over the counter: adapalene. It’s the first new OTC active ingredient to treat acne approved by the FDA in more than 30 years.

Differin® Gel is dermatologist-developed, and its active ingredient — adapalene — has been prescribed to over 40 million people globally for more than 20 years. It was approved by the FDA for over-the-counter use without a prescription in 2016.

Differin® Gel contains adapalene, a multi-benefit, dermatologist-recommended retinoid, available without a prescription, to clear breakouts where they start (deep in the pores); prevent acne before it begins; and, as a result, restore the skin’s texture and tone.

Yes, Differin® Gel is dermatologist developed and includes a dermatologist-recommended retinoid.
According to the American Academy of Dermatology’s (AAD) therapeutic treatment guidelines, topical retinoids like adapalene are recommended as a primary therapy for initial treatment of mild and moderate acne, even ahead of popular over-the-counter products that contain salicylic acid. The AAD is the largest organization of dermatologists (over 19,000 worldwide) who provide public education about dermatology and dermatologic health.