Cleanse
Cleanse with Daily Oil-Free Hydrating
Cleanser for a minimum of 30 seconds to help dissolve surface oil & impurities. Pat dry with
a towel.
NEW
NEW
NEW
Rx-Strength
Differin Epiduo Acne Gel
Differin Epiduo Acne Gel is the first clinically proven dual-active formula containing benzoyl peroxide & retinoid adapalene to help clear & prevent acne approved by FDA for OTC.
Dual actives retinoid adapalene & benzoyl peroxide are clinically proven to help clear & prevent acne. Treats 3 causes of acne by killing acne-causing bacteria, clearing clogged pores, & reducing inflammation. Starts killing acne-causing bacteria from day one for consistency clearer skin over time. Clinically proven & effective for all skin tones & types. Treats acne to help improve skin texture, tone, & radiance. Fights acne with no prescription needed. Recommended by dermatologists for over 15 years. Available in an easy-to-use pump (1.6 oz & 0.53 oz).
How to Use in a Routine
Differin Epiduo is a dual active Rx-strenth acne
treatment containing
benzoyl peroxide & adapalene retinoid to treat & help prevent acne. Apply to the full face day or night, but not both to help mitigate irritation. Use consistently for 12 weeks for best results.
benzoyl peroxide & adapalene retinoid to treat & help prevent acne. Apply to the full face day or night, but not both to help mitigate irritation. Use consistently for 12 weeks for best results.
Treat
Apply a pea-sized amount of Differin
Epiduo acne treatment once daily AM or PM to the full face to effectively help clear acne.
Moisturize
Apply the Oil Absorbing
Moisturizer with
Sunscreen in the AM to
help support the skin
barrier. Apply liberally 15
minutes before sun
exposure & reapply at
least every two hours.
Optional step
Patch
Apply Differin Fast Fix Patches to emerging pimples or Differin Skin Restore Patches to white head or gunk-filled pimples as needed to help spot treat. Not all patches are formulated the same- know which type works best for your acne.
Repair
Repair the skin with Differin Dark Spot Correcting Serum or Differin Scar Gel to help soothe the skin & reduce the appearance of post-acne marks & discoloration as needed.
Patch
Patches often work
best when applied
directly to clean, dry
skin. Leave on for a
minimum of 6-8 hours.
Repair
Apply post-acne
treatments after
cleansing but before
moisturizing.
Remember: Consistency matters more than intensity.
Frequently Asked Questions
How long does it take to see results when using Differin Epiduo?
Some people see results in as little as a week, for others it may take longer. In clinical studies, acne continued to improve over several months. Consistent use is important. If you have been using Differin Epiduo consistently and have not seen any improvement, consider consulting a dermatologist.
How often should I apply Differin Epiduo?
Use Differin Epiduo once a day, either in the morning or at night. If your skin feels dry, you can use a moisturizer more often, as needed. You can start slow by using Differin Epiduo every other day or every third day, gradually increasing to daily use. Using more than once a day may result in irritation.
Can I use moisturizer with Differin Epiduo? What skin treatments should I avoid?
Yes, moisturizer is recommended in the morning and night. Use a moisturizer after applying Differin Epiduo. Look for moisturizers with ingredients that support the skin's barrier. To avoid risk of irritation avoid products with chemical or physical exfoliants or other retinol products. Tell your facialist before receiving a treatment and avoid waxing.
Is it safe to use Differin Epiduo while pregnant or breastfeeding?
If you are pregnant or breastfeeding, ask a doctor before using Differin Epiduo.
Does Differin Epiduo product bleach fabrics?
All products containing Benzoyl Peroxide can bleach fabrics, including Differin Epiduo. We recommend using white or light colored linens while using this product. Put clothes on before applying Epiduo and avoid contact of Epiduo on hair and dyed fabrics. Wash hands thoroughly after applying Differin Epiduo.
All Ingredients
Adapalene 0.1% and Benzoyl Peroxide 2.5%
Acrylamide/Sodium, Acryloyldimethyltaurate Copolymer, Docusate Sodium, Edetate Disodium, Glycerin, Isohexadecane, Poloxamer 124, Polysorbate 80, Propylene glycol, Purified water, and Sorbitan Oleate
Our Misson
How it Works
Learn how Rx- strength Differin Epiduo Acne Gel can treat & help prevent acne with two key active ingredients.
Related Products
Reviews
Rated 5 out of
5
by
YuliaM from
Best acne gel to clear AND prevent ace !
I’ve been using the differin epiduo acne gel one a day for the past 4 weeks and I can honestly say it’s made such a difference in my skin! I apply every night after washing my face and gently patting it dry, and I’ve noticed fewer breakouts, smoother skin and a more even complex .
This acne treatment combines adapalene 0.01% (a retinoid) and benzoyl peroxide 2.5% to help treat acne at the source, clear existing breakouts, and helps prevent new ones from forming.
My skin looks so much healthier if you’ve been looking for something to help with stubborn acne, this has definitely been worth adding to my skincare routine 💜
Date published: 2026-08-04
Rated 5 out of
5
by
AmandaA from
I’m very very happy with my results from using this kit!
The very first night I tried this combo out I saw immediate results with my acne. I was actually shocked. I was using a much more harsh face wash before I started on this regimen, and so I think the gentle skin Cetaphil face wash really helped my skin! It’s a great idea having the adapalene and benzoyl peroxide combined into one product too! I had used adapalene gel and benzoyl peroxide bar soap separately before, but having the 2 medicines combined into 1 was really nice. Also the cetaphil moisturizing lotion is really good too, it doesnt burn my acne inflamed skin and really hydrates my skin so that’s it’s glowy. I’m very happy with the results using this kit!
Date published: 2026-08-17
Rated 5 out of
5
by
MorryB from
The ultimate acne fighting combo
I’ve used this gel for one month and Really like what it does for my skin, especially for keeping sebaceous plugs under control. I love that this combines adapalene and benzoyl peroxide in one gel so I don’t have to use or mix separate products anymore. My skin has looked so much better since using it and I’ve been really happy with the results. The biggest thing to be aware of is that benzoyl peroxide can be drying, so you may need to to alternate days or build up to daily use depending on how your skin tolerates it. Overall,I really like the convenience of having both acne treatments together and, more importantly,I’ve seen a noticeable improvement in my skin.
Date published: 2026-07-30
Rated 5 out of
5
by
RoxanaM from
Excellent product for acne
Í really enjoyed trying Differrin Epiduo Acne Gel. The combination of Adapalene 0.1% and benzoyl peroxide 2.5% makes the formula feel effective and well designed for acne-prone skin. With consistency use , I noticed my skin looked cleaner and my breakout were more manageable. The product was easy to apply, and I also appreciated the gentle cleanser and moisturizer included in the package. The packaging was simple, convenient.end well presented. Overall, I am happy with my experience and would recommend giving it a try if you are looking for and effective treatment of acne treatment
Date published: 2026-07-24
Rated 5 out of
5
by
LilianDenisseJ from
The Differin Epiduo Acne Gel has a lightweight texture that is easy to apply and absorbs well in the skin. I like that it feels clean and non greasy after application. With consistent use, my skin looks clearer and smoother, and I appreciate the simple pa
The Differin Epiduo Acne Gel has a lightweight texture that is easy to apply and absorbs well in the skin. I like that it feels clean and non greasy after application. With consistent use, my skin looks clearer and smoother.
I did notice some mild irritation and redness when I first started using it, but it was manageable and improved as my skin adjusted to the product. I also like the packaging because it is compact simple, and easy to use. Overall, I appreciate that the product is convenient to apply and easy fits into my skincare routine.
I was glad that it caused no irritation or redness on my skin.
Date published: 2026-08-25
Rated 5 out of
5
by
ErinW from
AMAZING!
My boyfriend ended up taking this product from me because of how great it was working. It’s so effective and easy to use consistently. We both used it for 4 weeks before he ended up buying another bottle for us! No irritation or redness, just clear skin
Date published: 2026-08-28
Rated 5 out of
5
by
DianaV from
Effective for reducing breakouts, but it may cause some dryness at first
I've been using Differin Epiduo Acne Gel consistently and I've noticed an improvement in my skin. It helps reduce breakouts and makes my skin look clearer, although it can cause some dryness at first.
Date published: 2026-08-29
Rated 4 out of
5
by
CShaw from
Great first impression, but the smell is STRONG
This is only my first night using it, so this is more of a first impression than a full review. I really like the packaging, and the gel feels very lightweight on my skin. My only complaint so far is the smell. It has a pretty strong chemical smell that lingers, although I am very sensitive to smells, so other people may not notice it as much.
It is way too early to tell whether it is helping my acne, but I have used regular Differin adapalene before. I do think this is worth the price, and it is really nice to finally see an adapalene and benzoyl peroxide combination available over the counter.
Date published: 2026-07-16