10% Benzoyl Peroxide Spot Treatment

The strongest concentration of benzoyl peroxide available over the counter to spot treat acne.

10% Benzoyl Peroxide Acne Spot Treatment is designed to target pop-up acne spots, blackheads & whiteheads helping to visibly reduce acne size and redness after 1 day. This 4-in-1 treatment helps kill acne-causing bacteria, clear blemishes & helps prevent future breakouts which improves skin’s texture.​

 

Active ingredients:
10% Benzoyl Peroxide
How to Use in a Routine
Benzoyl peroxide is a powerful acne fighting ingredient that can be applied day & night to help kill acne-causing bacteria & treat acne. Benzoyl peroxide spot treatments are available over the counter in various concentrations- be sure to use the concentration most suitable for your skin.
{{imageAlt}}
Cleanse
Use a cleanser best suited for your skin like the Differin Daily Hydrating, 5% Benzoyl Peroxide, or 10% Benzoyl Peroxide cleanser. Apply for a minimum of 30 seconds daily to prep the skin for acne treatments. Pat dry with a towel.​
{{imageAlt}}
Treat
Apply a thin layer of Differin 10% Benzoyl Peroxide Spot Treatment to help spot treat acne three times daily as needed.
{{imageAlt}}
MOISTURIZE
Apply the Oil Absorbing Moisturizer with Sunscreen in the AM to help support the skin barrier. Apply liberally 15 minutes before sun exposure and reapply at least every 2 hours. ​
Optional step

PATCH

Apply Differin Fast Fix Patches to emerging pimples or Differin Skin Restore Patches to white head or gunk-filled pimples as needed to help spot treat. Not all patches are formulated the same- know which type works best for your acne.


Repair

Repair the skin with Differin Dark Spot Correcting Serum or Differin Scar Gel to help soothe the skin & reduce the appearance of post-acne marks & discoloration as needed.

{{imageAlt}}
PATCH
Patches often work best when applied directly to clean, dry skin. Leave on for a minimum of 6-8 hours.​
{{imageAlt}}
REPAIR
Apply post-acne treatments after cleansing but before moisturizing. ​
Remember: Consistency matters more than intensity.

FAQ's

bannerImage- what to expect
What does Differin® Gel do to clear acne?

Differin® Gel contains adapalene, a type of retinoid. Topical retinoids, like Differin® Gel, play a crucial role in the treatment of acne. Retinoids have vitamin A activity which helps regulate cell turnover to make sure your skin goes through the right process, creating a healthier environment for skin. Regulating cell turnover helps to keep the pores from clogging and target acne before it even starts. Don’t think of Differin® Gel as a spot treatment only to be used when acne rears its ugly head. In fact, if used daily, Differin® Gel stops new acne from forming, resulting in improved skin tone and texture.

What is Differin® Gel?

Differin contains the only full prescription fighting retinoid available over the counter: adapalene. It’s the first new OTC active ingredient to treat acne approved by the FDA in more than 30 years.

How long has Differin® Gel been on the market?

Differin® Gel is dermatologist-developed, and its active ingredient — adapalene — has been prescribed to over 40 million people globally for more than 20 years. It was approved by the FDA for over-the-counter use without a prescription in 2016.

What makes Differin® Gel unique from other options currently available?

Differin® Gel contains adapalene, a multi-benefit, dermatologist-recommended retinoid, available without a prescription, to clear breakouts where they start (deep in the pores); prevent acne before it begins; and, as a result, restore the skin’s texture and tone.

Is Differin® Gel dermatologist developed and tested?

Yes, Differin® Gel is dermatologist developed and includes a dermatologist-recommended retinoid.
According to the American Academy of Dermatology’s (AAD) therapeutic treatment guidelines, topical retinoids like adapalene are recommended as a primary therapy for initial treatment of mild and moderate acne, even ahead of popular over-the-counter products that contain salicylic acid. The AAD is the largest organization of dermatologists (over 19,000 worldwide) who provide public education about dermatology and dermatologic health.

All Ingredients

Benzoyl Peroxide 10 %, Acrylates Copolymer, Carbomer, Diethylhexyl Sodium Sulfosuccinate, Disodium EDTA, Glycerin, Poloxamer 182, Propylene Glycol, Silica, Sodium Hydroxide, Water.


Our Misson

How it Works

Learn how 10% Benzoyl Peroxide Spot Treatment works to kill acne-causing bacteria & treat acne.


Reviews

Rated 4 out of 5 by from Game-Changer for Breakouts I tried the Differin 10% BPO Spot Treatment, and I have to say, it did make a difference! First off, I love how easy it is to apply. Just a small dab on the problem area before bed, and by morning, I can already see a noticeable difference. The redness and swelling are significantly reduced, and it doesn't leave my skin feeling dry or irritated like some other treatments I've tried. Plus, the 10% benzoyl peroxide formula is strong enough to tackle a pimple without being too harsh. This is something good to keep around whenever a bump appears. If you're struggling with breakouts and need something that really works, give this a try!!
Date published: 2024-07-26
Rated 4 out of 5 by from Concentrated. Effective if used with care. So we all know benzoyl peroxide has been top tier in acne treatments. This is a very concentrated form. It absolutely is effective, I found that washing your face before bed, toning, and putting on a light moisturizer BEFORE this can combat any excess drying that may occur. You want to remember that balance is key, breakouts can occur due to an imbalance in this skin, lacking or excess. So having a cleansed and moisturized face prior, can really make or break how this works for you. I love using it before bed because the skin has all night to absorb the product, and you wake up to a much clearer and fresher complexion.
Date published: 2024-07-24
Rated 4 out of 5 by from Differin 10% BPO clears blemishes fast and gently. I've been using Differin 10% BPO Spot Treatment for a couple of weeks now, and it has become a game-changer in my skincare routine. The 10% benzoyl peroxide formula is potent, yet surprisingly gentle on my skin. I noticed that it dries up blemishes much quicker than other spot treatments I've tried. I love how easy it is to apply—just a small amount on the problem area, and within a day or two, the breakout has significantly reduced in size and redness. It's not too drying either, which I appreciate because my skin tends to be sensitive. I use it as needed, and it hasn't caused any irritation. Highly recommend this if you're looking for a powerful spot treatment that delivers results fast!
Date published: 2024-09-06
Rated 5 out of 5 by from Reduced spots so quick! Okay so I was super skeptical about this at first because I’ve tried literally everything for my random pimples and nothing really works. But wow, this stuff is actually magic. I put it on a stubborn spot at night and literally by the next morning it was way smaller and way less red. The texture is a little thick but it doesn’t feel gross or sticky, and it dries down nicely so I can put my moisturizer over it without any weird feeling. I’ve been using it for a couple of weeks now and my breakout spots don’t last nearly as long, which is honestly life changing. This is officially my go to “emergency zit zapper” and I tell anyone with annoying pimples to give it a try because it actually works.
Date published: 2025-11-24
Rated 5 out of 5 by from Game Changer! As someone who has struggled with stubborn acne scars for months, I was thrilled to see noticeable improvements after incorporating this product into my routine. The treatment is particularly effective on those hard-to-get-rid-of scars, gradually fading them and leaving my skin looking clearer and more even-toned. I also found it incredibly useful for targeting the nose and pore areas. The formula spreads easily and works wonders in reducing the appearance of pores and preventing new breakouts. One of the best aspects of this spot treatment is its ability to deliver results without causing excessive dryness or irritation, which can be a common issue with high-concentration benzoyl peroxide products.
Date published: 2024-08-06
Rated 5 out of 5 by from Value Differin Acne 10% Benzoyl Spot Treatment is a potent product designed to tackle stubborn acne. With its high concentration of benzoyl peroxide, it effectively targets and reduces breakouts by eliminating acne-causing bacteria and unclogging pores. Users often see noticeable improvements in their skin's clarity and texture with regular use. However, its strong formulation may cause dryness or irritation, so it's advisable to start with a small amount and use a good moisturizer. Overall, it's a powerful option for those dealing with persistent acne and smell good and good price
Date published: 2024-07-17
Rated 4 out of 5 by from Good Affordable Acne Product! I really enjoyed trying out the 10% BPO Spot Treatment by Differin. I’ve used their products before, and they definitely work well if you struggle with acne breakouts. I am not usually someone who gets serious breakouts, but I deal with bigger breakouts when I do get them from time to time. This product works great on chin and forehead breakouts. You only need a little bit because this product contains strong chemical ingredients. Only use a little because using too much can cause skin irritation. Highly recommend if you are looking for an affordable acne treatment!
Date published: 2024-07-17
Rated 5 out of 5 by from Love I was so excited to try Differin 10% BPO Spot Treatment. The light texture absorbs quickly, leaving my skin feeling smooth. While I can't fully attest to its effectiveness, I'm very impressed with the results so far. I appreciate of treatment that immediately starts to kill acne-causing bacteria and visibly reduces acne in 1 day.Overall, I am very pleased with this product and would recommend it to anyone looking for a treatment, effective. If you are like me and want to acne, I recommend using a product for an extended period of time to see optimal results.
Date published: 2024-07-24
  • y_2026, m_7, d_20, h_7
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.48
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_266
  • loc_en_US, sid_0299053078, prod, sort_[SortEntry(order=RELEVANCE, direction=DESCENDING)]
  • clientName_differin
  • bvseo_sdk, dw_cartridge, 18.2.0, p_sdk_3.2.0
  • CLOUD, getReviews, 5ms
  • reviews, product